The aim of this study was to evaluate the effect of tick saliva on endoplasmic stress in PMJ2-R cells infected with tick-borne encephalitus virus. The endoplasmic stress was analysed through 3 different branches of unfolded protein response: ATF-6, PERK and IRE-1. Moreover, the thesis deals with the effect of tick salivary protein Iristatin on endoplasmic stress in infected cells.
unfolded protein response, tick saliva, TBEV, endoplasmic stress, Iristatin
Rozsah průvodní práce
61
Jazyk
CZ
Anotace
-
Anotace v angličtině
The aim of this study was to evaluate the effect of tick saliva on endoplasmic stress in PMJ2-R cells infected with tick-borne encephalitus virus. The endoplasmic stress was analysed through 3 different branches of unfolded protein response: ATF-6, PERK and IRE-1. Moreover, the thesis deals with the effect of tick salivary protein Iristatin on endoplasmic stress in infected cells.