Informace o kvalifikační práci Cytotoxicity screen of the acyclic nucleoside phosphonates against bloodstream stage of <i>Trypanosoma brucei</i> and validation of their putative target hypoxanthine/xanthine/guanine phosphoribosyltransferase
- Pro tuto VŠKP nejsou definovány žádné údaje, u kterých by bylo požadováno jejich vyplnění.
Hlavní téma
Purine analogues as potential inhibitors of purine salvage pathway in Trypanosoma brucei
Hlavní téma v angličtině
Cytotoxicity screen of the acyclic nucleoside phosphonates against bloodstream stage of Trypanosoma brucei and validation of their putative target hypoxanthine/xanthine/guanine phosphoribosyltransferase
Název dle studenta
Cytotoxicity screen of the acyclic nucleoside phosphonates against bloodstream stage of Trypanosoma brucei and validation of their putative target hypoxanthine/xanthine/guanine phosphoribosyltransferase
The aim of this study was to test several compounds of acyclic nucleoside phosphonates (ANPs), which are thought to inhibit the purine salvage pathway enzyme hypoxanthine/xanthine/guanine phosphoribosyltransferase (HGXPRT) of the bloodstream stage of Trypanosoma brucei. Further we intended to elucidate if HGXPRT enzymes are essential for the survival of the bloodstream T.brucei.
Anotace v angličtině
The aim of this study was to test several compounds of acyclic nucleoside phosphonates (ANPs), which are thought to inhibit the purine salvage pathway enzyme hypoxanthine/xanthine/guanine phosphoribosyltransferase (HGXPRT) of the bloodstream stage of Trypanosoma brucei. Further we intended to elucidate if HGXPRT enzymes are essential for the survival of the bloodstream T.brucei.
Klíčová slova
Trypanosoma brucei, HAT, Human African Trypanosomiasis, RNAi, HGXPRT, acyclic nucleoside phosphonates, ANP, purine salvage pathway, AlamarBlue, bloodstream T.brucei
Klíčová slova v angličtině
Trypanosoma brucei, HAT, Human African Trypanosomiasis, RNAi, HGXPRT, acyclic nucleoside phosphonates, ANP, purine salvage pathway, AlamarBlue, bloodstream T.brucei
Rozsah průvodní práce
40
Jazyk
AN
Anotace
The aim of this study was to test several compounds of acyclic nucleoside phosphonates (ANPs), which are thought to inhibit the purine salvage pathway enzyme hypoxanthine/xanthine/guanine phosphoribosyltransferase (HGXPRT) of the bloodstream stage of Trypanosoma brucei. Further we intended to elucidate if HGXPRT enzymes are essential for the survival of the bloodstream T.brucei.
Anotace v angličtině
The aim of this study was to test several compounds of acyclic nucleoside phosphonates (ANPs), which are thought to inhibit the purine salvage pathway enzyme hypoxanthine/xanthine/guanine phosphoribosyltransferase (HGXPRT) of the bloodstream stage of Trypanosoma brucei. Further we intended to elucidate if HGXPRT enzymes are essential for the survival of the bloodstream T.brucei.
Klíčová slova
Trypanosoma brucei, HAT, Human African Trypanosomiasis, RNAi, HGXPRT, acyclic nucleoside phosphonates, ANP, purine salvage pathway, AlamarBlue, bloodstream T.brucei
Klíčová slova v angličtině
Trypanosoma brucei, HAT, Human African Trypanosomiasis, RNAi, HGXPRT, acyclic nucleoside phosphonates, ANP, purine salvage pathway, AlamarBlue, bloodstream T.brucei